Port Melbourne is an inner suburb of Melbourne, Australia, 3 km south-west from the Melbourne central business district. It is split between the local government areas of Melbourne and Port Phillip. The area to the north of the West Gate Freeway is in the City of Melbourne. 

Historically it was known as Sandridge and developed as the City's second port, linked to the nearby Melbourne CBD.

The formerly industrial Port Melbourne has been subject to intense urban renewal over the past two decades. As a result, Port Melbourne is a diverse and historic area, featuring industrial and port areas along the Yarra, to open parklands, bayside beaches, exclusive apartments and Bay Street's restaurants and cafes. The suburb also forms a major transport link from east to west, home to one end of the West Gate Bridge.